The Extrinsic Skin Ageing: Oxidative Stress, DNA Damage and Glycation

The Extrinsic Skin Ageing Mechanisms

We don't have much control on the intrinsic ageing factors as most of them are genetic predisposition such as skin colour and genetic skin sensitivity. However, we have more influences on the extrinsic skin ageing. By understanding the extrinsic skin ageing mechanisms, we can learn how to slow down the skin ageing process.

1. Oxidative Stress and Skin Ageing

As part of the normal metabolism, your body generates Reactive Oxygen Species (ROS). Under normal circumstances, ROS don't cause any harm to your body. However, when your body is exposed to harsh conditions, be it physical or mental; it may generate too many ROS than it can handle. They trigger oxidative stress in your body.

Oxidative Stress has damaging effects on your body. It causes damage to body cells. It damages the collagen and elastin fibres, triggering the appearance of signs of ageing such as wrinkles and sagging skin.

To help protect your skin from free radical damage, use skincare products that contain Resveratrol, a superantioxidant found in the skin of red grape. Studies suggested that it has greater antioxidant capacity than vitamin A, C, E, Idebenone, Catechin in teas, Ellagic Acid in pomegranates, Epicatechin in cocoa, Gallic Acid in blueberries and Gallocatechin (in adzuki beans). Resveratrol is one of bioactives in award-winning Bio-Collagen Serum, the extra firming and lifting rejuvenating serum to reduce signs of ageing, soothe and protect skin from free radicals, oxidative stress and environmental ageing.


2. Inflammatory Skin Ageing

Inflammation can be a crucial part of the body's defense mechanism. Our body triggers acute inflammation to fight against infection or injury. In most cases, acute inflammation is a short-term and necessary process in order for the body to renew itself and repair damages. It is part of the healing process too.

However, when the inflammation lasts longer than it is supposed to be, it has damaging effects to the body. Known as a chronic inflammation, it has been associated with some diseases such as diabetes, alzheimer’s disease, cardiovascular disease and inflammatory skin ageing. 

To help protect skin from inflammatory ageing, look for skincare products with  Blue Chamomile and Turmeric. Blue Chamomile contains Alpha Bisabolol and Bisabolol Oxides, the substances known for their anti-irritant, anti-inflammatory and anti-microbial properties. While Turmeric contains a deep-orange colour substance called Curcumin, an excellent antioxidant and anti-inflammatory. 

Multi-award-winning Antioxidant Youthful Essence has been formulated with Turmeric, Blue Chamomile, Ginkgo, Allantoin and pro-vitamin B5 that help protect skin against inflammatory ageing caused by environmental pollution.


3. DNA Damage and Skin Cancer

A prolonged exposure to UV radiation, especially UVB, is the main cause of DNA damage. DNA damage potentially leads to the development of skin cancer. In addition to that, it also triggers the premature appearance of signs of ageing such as wrinkles, sagging skin and hyperpigmentation.

Wear a sunblock to help prevent DNA damage and skin cancer while also reduce the appearance of sun-induced skin ageing. Look for skincare products with Niacinamide and N-Acetyl Glucosamine. These biotechnology ingredients soften the appearance of wrinkles, lines and pigmentation spots. Award-winning Bio-Collagen Ageless Cream has been formulated with 10 bioactive ingredients including 24-karat Nano Gold particles, Niacinamide, N-Acetyl Glucosamine, Coenzyme Q10 and Nano Hyaluronic Acid to lift, firm and restore skin's youthfulness. With regular daily use, this regenerating cream boosts skin renewal, diminish the appearance of age spots, wrinkles and sagging skin.

4. Glycation and Advanced Glycation End Products (AGEs) 

Sugar has the ability to attach itself to a protein molecule such as collagen and elastin fibres. This process is known as Glycation. Glycation is a normal process triggered by the presence of sugar in your body. The end result of Glycation is the formation of harmful molecules known as Advanced Glycation End Products (AGEs) that can cause serious damage to your body.

Gylcation causes a damage to collagen, elastin and other skin's components. It accelerates the skin ageing process and triggers the appearance of wrinkles, lines and sagging skin. 

To slow down the skin ageing process, limit the exposure to sun especially during peak hours, usually from 10am to 4pm. During the day, wear sunglasses to protect the eyes and fragile skin around the eyes. Reapply sunscreen after sweating or swimming.



Henry Tianus is a multi-award-winning Anti-Ageing Scientist based in London, UK. Read >>>



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Sources: Fighting against Skin Aging, The Way from Bench to Bedside, Cell Transplantation, 2018 May, 27(5): 729–738; What Controls Variation in Human Skin Color?, PLOS Biology, 2003 Oct; 1(1): e27.

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