The Extrinsic Skin Ageing: Oxidative Stress, DNA Damage and Glycation


Oxidative stress causes damage to body cells, collagen and elastin fibres; triggering the appearance of wrinkles, sagging skin and other signs of ageing."


There are various internal and external factors that have an impact on the ageing process of human body. By birth, each of us carries a set of genetic predispositions such as the colour of the skin, hair and eyes. Depending on our lifestyle and where we live, we are subjected to the extrinsic ageing factors such as extreme weather conditions and pollution.

While we don't have much control on the intrinsic ageing factors, we can limit our exposure to the extrinsic ageing factors. As the largest organ in our body, our skin protects the body from various external aggressors including pathogenic microorganisms. Due to the constant exposure to harsh elements, our skin is prone to premature damage and ageing. By understanding the skin ageing mechanisms, we can slow down the ageing process.

Oxidative Stress and Skin Ageing

As part of the normal metabolism, your body generates Reactive Oxygen Species (ROS). In healthy individuals with a strong immune system, ROS may not harm the body. However, when there are too many ROS generated in the body, they can trigger oxidative stress. Oxidative stress causes damage to body cells including skin cells. It weakens the collagen and elastin fibres, over time, it triggers the appearance of wrinkles, sagging skin and other signs of ageing.

To help protect your skin from oxidative stress, use skincare products that contain resveratrol, a superantioxidant found in the skin of red grape. Studies suggested that it has greater antioxidant capacity than vitamin A, C, E, Idebenone, Catechin (in teas), Ellagic Acid (in pomegranates), Epicatechin (in cocoa), Gallic Acid (in blueberries) and Gallocatechin (in adzuki beans). Antioxidant helps neutralise and prevent free radicals from triggering oxidative stress in your body.

Resveratrol is one of the bio-actives in award-winning Bio-Collagen Serum, the extra firming and lifting rejuvenating serum to reduce various signs of ageing. This light, quickly-absorbed facial serum soothes and protects the skin from free radicals, oxidative stress and environmental ageing.


 Facelift in a bottle! Delighted with my purchase. Within minutes my skin feels tighter and looks fresher.” Rachel, UK learn more >>>


Inflammatory Skin Ageing

Inflammation can be a crucial part of the body's defense mechanism. Our body triggers acute inflammation to fight an infection or injury. Acute inflammation is a short-term process in our body. It is a crucial part of the healing process in the body.

When the inflammation lasts longer than it is supposed to be, it can cause more damage to our body. Known as a chronic inflammation, it has been associated with some diseases including diabetes, alzheimer’s disease, cardiovascular disease and inflammatory skin ageing. 

To help protect your skin from inflammatory ageing, look for skincare products that contain niacinamide (vitamin B3) and turmeric. Studies showed that niacinamide strengthens the skin's barrier function and boosts the collagen, elastin and other protein synthesis in the skin by up to 100%. While curcumin, the active phytochemical of turmeric has been shown to be an excellent antioxidant and anti-inflammatory substance. 

The multi-award-winning Antioxidant Youthful Essence has been formulated with niacinamide, allantoin, turmeric and blue chamomile to prevent  inflammatory skin ageing caused by pollution and other extrinsic ageing factors.


This is amazing! I noticed a difference round my eyes after the first application. My skin felt tighter and firmer after just a couple of days." Best Wrinkle Zapper, Natural Health learn more >>>


DNA Damage and Skin Cancer

A prolonged exposure to UV radiation, especially UVB, is the main cause of DNA damage. DNA damage potentially leads to the development of skin cancer. It also triggers the premature appearance of wrinkles, sagging skin, hyperpigmentation and other signs of ageing.

To help prevent DNA damage and skin cancer, always wear sunblock whenever you spent time outdoor for a long period of time. It is best to avoid prolonged exposure to sunlight during peak hours, usually between 10am and 4pm in summer. During the day, wear sunglasses to protect the eyes and fragile skin around the eyes. Reapply sunblock after sweating or swimming.

To reduce the appearance of sun-induced skin damage and ageing, look for skincare products that contain n-acetyl glucosamine and niacinamide. Studies showed that these two ingredients soften the appearance of wrinkles, lines and pigmentation spots.

The award-winning Bio-Collagen Ageless Cream has been formulated with 10 bioactive ingredients including niacinamide, n-acetyl glucosamine, ultra-low-molecular-weight hyaluronic acid and 24-karat gold nanoparticles to lift, firm and restore skin's youthfulness. With regular daily use, this regenerating cream boosts skin renewal, diminishes the appearance of age spots, wrinkles and sagging skin.

Glycation and Advanced Glycation End Products (AGEs) 

Sugar has the ability to attach itself to a protein molecule such as collagen and elastin fibres. This process is known as Glycation. Glycation is a common process in your body triggered by the presence of sugar. The end result of Glycation is the formation of harmful molecules known as Advanced Glycation End Products (AGEs) that can cause serious damage to your body.

Gylcation weakens collagen, elastin and other skin's components. It accelerates the skin ageing process and triggers the appearance of wrinkles, lines and sagging skin. To help strengthen the collagen, elastin and other skin's components, use skincare products that contain niacinamide (vitamin B3) and phyto-antioxidants such as Antioxidant Youthful Essence and Bio-Collagen Ageless Cream.


" Argan oil plumps, Niacinamide tackles pigmentation and rosacea and 24 Carat Gold smooths wrinkles. An all-round winner." Vitality, BABTAC (British Association of Beauty Therapy & Cosmetology) learn more >>>



Henry Tianus is a multi-award-winning Anti-Ageing Scientist based in London, UK. Henry Tianus has been listed as The Recognised Institute Practitioner at The Institute of Traditional Herbal Medicine and Aromatherapy (ITHMA), London (UK) since 2005. Henry Tianus's articles have been read by people in more than 100 countries with USA and UK at the top of the list. Join Henry Tianus eNewsletter to receive the latest health and wellbeing tips. 

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Scientific Sources: Fighting against Skin Aging, The Way from Bench to Bedside, Cell Transplantation, 2018 May, 27(5): 729–738; What Controls Variation in Human Skin Color?, PLOS Biology, 2003 Oct; 1(1): e27.

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