The Best Hyaluronic Acid: A Guide To Facial Serums and Creams


" With the molecular weight of less than 6,000 dalton (0.0000000000000000001 gram), ultra-low-molecular-weight hyaluronic acid is the most effective type of hyaluronic acid in skincare products."


Naturally found in our body especially in the joints and skin, hyaluronic acid gives our skin its youthful plumpness. It is often used as the active ingredient for anti-ageing skincare products. It acts as a water reservoir for the skin cells to prevent dryness and dehydration. The hyaluronic acid levels in our skin decline with age, causing the appearance of wrinkles, lines and sagging skin. Fortunately, facial serums and creams that contain hyaluronic acid help minimise the signs of ageing.

Hyaluronic acid in skincare products is made of sodium hyaluronate. Based on its molecular weight, there are different types of sodium hyaluronate. The most effective hyaluronic acid is the one with the lowest molecular weight which penetrates deeper into the skin. The deeper hyaluronic acid goes into the skin, the better the results. Before you buy facial serum and cream that are made with hyaluronic acid, make sure you know which type of hyaluronic acid is the most potent one.

1. Ultra-Low-Molecular-Weight Hyaluronic Acid

Ultra-low-molecular-weight hyaluronic acid is made of sodium hyaluronate with an average molecular-weight of less than 6,000 dalton (1 dalton = 0.0000000000000000000000166 gram). By far, this is the best hyaluronic acid found in facial serums and creams. Hyaluronic acid ULMW has the highest skin penetration ability among all types of hyaluronic acid. It is one of the most effective ingredients to restore the youthfulness of the skin from within.

As an anti-ageing scientist, I highly recommend to use facial serum and cream that are made with ultra-low-molecular-weight hyaluronic acid. It is an expensive ingredient but it is worth it. If your skin shows prominent signs of ageing, apply Bio-Collagen Serum to freshly-cleansed face and neck, morning and evening. This powerful anti-ageing serum has been formulated with ultra-low-molecular-weight hyaluronic acid and 24-karat gold nanoparticles to rejuvenate skin cells. It also contains resveratrol, ferulic acid and coenzyme Q10 to strengthen skin's defense mechanism and protect skin cells from biological and environmental ageing factors.


Facelift in a bottle! Delighted with my purchase. Within minutes my skin feels tighter and looks fresher.” Rachel, UK learn more >>>

2. Super-Low-Molecular-Weight Hyaluronic Acid

Hyaluronic acid SLMW has an average molecular-weight of less than 50,000 dalton. It isn't as effective as Hyaluronic Acid ULMW, however, it is better than the other three types of hyaluronic acid below.

3. Extra-Low-Molecular-Weight Hyaluronic Acid

Hyaluronic acid ELMW has an average molecular-weight of 110,000 dalton. 

4. Low-Molecular-Weight Hyaluronic Acid

Hyaluronic acid LMW has an average molecular-weight of 1,000,000 dalton.

5. High-Molecular-Weight Hyaluronic Acid

This is the most common type of hyaluronic acid in skincare products. With a molecular-weight of up to 1,500,000 dalton, hyaluronic acid HMW has the lowest skin penetration ability. It is the cheapest hyaluronic acid and most widely used in skincare products, however, high-molecular-weight hyaluronic acid is also the least effective one.

The Alternative Way to Boost Skin's Hyaluronic Acid Levels

Hyaluronic acid serums and creams are not the only products that help replenish the skin's hyaluronic acid. There are few other ingredients that have been shown to boost the skin's hyaluronic acid levels such as:

1. Saccharide Isomerate

Extracted from the plants, saccharide isomerate boosts the skin's hydration levels and provides an instant, yet long-lasting protection against skin dryness and dehydration. It plumps up the appearance of the skin and smooths out wrinkles. A study showed that it increases the hyaluronic acid synthesis in the skin by up to 66%. Saccharide isomerate is the best alternative to hyaluronic acid for those with sensitive skin as it also soothes and calms sensitive skin.

Saccharide isomerate deeply hydrates the skin for up to 72 hours without leaving a greasy residue on the skin. It is quickly absorbed by the skin, hence it is suitable for all skin types from dry to oily skin. Both Rose Gold Anti-Ageing Soothing Serum and Rose Gold Anti-Ageing Soothing Cream have been formulated with saccharide isomerate and 24-karat gold nanoparticles to replenish skin's moisture and protect sensitive skin from signs of ageing. Both the serum and cream boost skin renewal and minimise the appearance of wrinkles, fine lines and other signs of ageing.


“ Five star! I’ve been using this moisturiser for over a month now and am super happy. I love how it works on my face! This face cream is light and silky and it makes my skin smooth and firm. It’s not greasy at all and it absorbs right in. It really feels like I am doing something special for myself when I put it on!" 
Julia, UK learn more >>>

2. N-Acetyl Glucosamine

Extracted from the shell of shellfish, n-acetyl glucosamine has been shown to reduce the appearance of wrinkles and pigmentation spots. Studies also showed that n-acetyl glucosamine boosts the production of hyaluronic acid in the skin and gently peels off dead skin cells. It works synergistically with niacinamide to diminish dark spots by reducing the excess production of melanin pigment in the skin. N-acetyl glucosamine is the best alternative to hyaluronic acid for those with pigmentation spots.

To reduce the signs of ageing and hyperpigmentation, apply Bio-Collagen Serum and Bio-Collagen Ageless Cream every morning and evening. These anti-ageing formulas have been specially developed using 10 active ingredients including n-acetyl glucosamine, niacinamide and ultra-low-molecular-weight hyaluronic acid to restore the youthfulness of the skin and even out complexion. Infused with 24-karat gold nanoparticles, Bio-Collagen serum and cream nourish and bring oxygen to the skin cells in the deeper layers of the skin.


" Argan oil plumps, Niacinamide tackles pigmentation and rosacea and 24 Carat Gold smooths wrinkles. An all-round winner." BABTAC (British Association of Beauty Therapy & Cosmetology) learn more >>>



Henry Tianus is a multi-award-winning Anti-Ageing Scientist based in London, UK. Henry Tianus has been listed as The Recognised Institute Practitioner at The Institute of Traditional Herbal Medicine and Aromatherapy (ITHMA), London (UK) since 2005. Henry Tianus's articles have been read by people in more than 100 countries with USA and UK at the top of the list. Join Henry Tianus eNewsletter to receive the latest health and wellbeing tips. 

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Scientific Sources: Low Molecular Weight Hyaluronic Acid: Its Effects on Epidermal Gene Expression & Skin Ageing, International Journal for Applied Science, English Edition, SOFW-Journal, 134, 11-2008.

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