N-Acetyl Glucosamine: How To Reduce Age Spots and Hyperpigmentation


" Studies showed that N-Acetyl Glucosamine reduces facial hyperpigmentation and protects skin cells from free radicals and oxidative stress."


What is N-Acetyl Glucosamine?

Known for its various health and skin benefits, N-Acetyl Glucosamine is a nano peptide naturally extracted from the outer shells of shellfish. Peptide is part of the protein structure that gives your skin strength and elasticity. 

N-Acetyl Glucosamine Boosts The Skin's Hyaluronic Acid Production

Due to its nano particle size, N-Acetyl Glucosamine can penetrate deeper into the skin; boosting the skin's hyaluronic acid synthesis and reducing inflammation. N-Acetyl Glucosamine is the basic component of hyaluronic acid, a major skin component that plays an important role in the youthfulness of your skin. It plumps up the appearance of your skin.

Just like with other skin components, the levels of hyaluronic acid in the skin decline with age, triggering the appearance of wrinkles, lines and other signs of ageing. Many studies showed that N-Acetyl Glucosamine helps reduce and reverse signs of ageing including age spots, hyperpigmentation, wrinkles, dryness and loss of skin volume.

N-Acetyl Glucosamine Reduces Facial Hyperpigmentation and Brightens Complexion

Adding years to your appearance more than wrinkles, age spots are the signs of accumulated skin damage over a period of time due to excessive exposure to UV radiation or hormonal changes during pregnancy and menopause.

Studies showed that N-Acetyl Glucosamine reduces facial hyperpigmentation by inhibiting the melanin production and protecting skin cells from free radicals and oxidative stress. The skin brightening effects of N-Acetyl Glucosamine is further boosted when it is mixed with niacinamide (vitamin B3) in a skincare formula.

The skin renewal, smoothing and brightening properties of N-Acetyl Glucosamine are similar to those of Alpha Hydroxy Acids. Even better, N-Acetyl Glucosamine is suitable for all skin types including hyper-sensitive skin. If you suffer from uneven skin tone and hyperpigmentation, use Henry Tianus Bio-Collagen Serum which has been developed using the art of nano bio-technology to rejuvenate the skin and bring out the youthful radiance from within. Formulated with 10 active ingredients including n-acetyl glucosamine, niacinamide, resveratrol, 24-karat gold and hyaluronic acid nano molecules to lift and firm the look of the skin while at the same time diminish the age spots, wrinkles and other skin imperfections. 


“ Facelift in a bottle! Delighted with my purchase. Within minutes my skin feels tighter and looks fresher.” Rachel, UK learn more >>>


Is N-Acetyl Glucosamine a Safe Skin Whitening Ingredient?

Skin Whitening Products are very popular in many countries, particularly in Asia and Africa. As an anti-ageing scientist, I formulate skincare products to help preserve the youthfulness of the skin. I believe that healthy skin is the key to a youthful appearance. Many whitening skincare products have been formulated with hydroquinone and kojic acid that may have adverse effects on skin health. I strongly recommend to read the ingredient list before you buy any skincare product. Hydroquinone has been banned in Europe for over the counter skincare or cosmetic products. However, some over the counter skincare products from USA and many other countries still contain hydroquinone.

The two ingredients that I use to reduce age spots and hyperpigmentation, N-Acetyl Glucosamine and Niacinamide have been proven to be safe and effective in slowing down the skin ageing process. The way these ingredients brighten the appearance of the skin is by preventing the excess melanin production and boosting skin cell renewal. 

N-Acetyl Glucosamine Reduces Wrinkles and Other Signs of Ageing

Numerous studies showed that N-Acetyl Glucosamine improves the appearance of ageing skin. It reduces wrinkles, lines, age spots, dryness and dehydration. The anti-ageing effects of N-Acetyl Glucosamine are due to its ability to boost hyaluronic acid synthesis and improve skin cell turnover. N-Acetyl Glucosamine strengthens skin matrix and restores the youthfulness of the skin. It helps unclog pores and gently peels off dead skin cells that makes it suitable for acne-prone skin too.

N-Acetyl Glucosamine in Anti-Ageing Skincare Products

Due to its excellent stability, skin penetrating and rejuvenating properties, N-Acetyl Glucosamine is one of the best anti-ageing ingredients for skincare products. I don't believe there is anything that can stop the ageing process completely, nevertheless, I do believe that anti-ageing skincare products can slow down the signs of ageing. I use a combination of n-acetyl glucosamine, niacinamide, stabilised vitamin E, hyaluronic acid and 24-karat nano gold particles in my award-winning anti-ageing moisturiser, Bio-Collagen Ageless Cream.


" Argan oil plumps, Niacinamide tackles pigmentation and rosacea and 24 Carat Gold smooths wrinkles. An all-round winner." BABTAC (British Association of Beauty Therapy & Cosmetology) learn more >>>


The Alternative Skin Brightening Ingredients

In adults, skin renews itself every 28 to 42 days. A healthy skin renewal is the key to prevent and reduce the appearance of age spots and hyperpigmentation. L-ascorbic acid, the most potent and active form of vitamin C is known to work synergistically with ferulic, alpha and beta hydroxy acids to boost skin cell renewal and regulate the production of melanin, the skin's pigment. The excess production of melanin in the skin is the main cause of hyperpigmentation and melasma.

L-ascorbic acid (vitamin C) along with ferulic, alpha and beta hydroxy acids are the alternative skin brightening ingredients; however, for sensitive and hyper-sensitive skin, the combination of n-acetyl glucosamine and niacinamide are the best as both have excellent soothing and calming properties. L-ascorbic, ferulic, alpha and beta hydroxy acids are excellent skin brightening ingredients for all skin types except for hyper-sensitive skin.

Day and Night Skin Brightening Serum Duo

Skin Brightening Serum Duo are a pair of synergistic day and night face serums, Antioxidant Youthful Essence and Overnight Skin Perfector. Both have been developed to work synergistically to speed up skin cell renewal and reduce the appearance of age spots, hyperpigmentation and other signs of ageing. Formulated with L-ascorbic, ferulic, alpha and beta hydroxy acids to even out skin tone and promote a radiant complexion. 

For best results, apply Antioxidant Youthful Essence to freshly cleansed face and neck every morning. Follow with moisturiser/sunscreen. In the evening, apply Overnight Skin Perfector to freshly cleansed face and neck avoiding the eye area; then apply Antioxidant Youthful Essence. Follow with moisturiser.


Synergistic day and night radiance boosting serums to renew the appearance of the skin, diminish dark spots and blemishes learn more >>>



Henry Tianus is a multi-award-winning Anti-Ageing Scientist based in London, UK. Henry Tianus has been listed as The Recognised Institute Practitioner at The Institute of Traditional Herbal Medicine and Aromatherapy (ITHMA), London (UK) since 2005. Henry Tianus's articles have been read by people in more than 100 countries with USA and UK at the top of the list. Join Henry Tianus eNewsletter to receive the latest health and wellbeing tips. 

 Click To Join Henry Tianus eNewsletter >>>  


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Scientific Sources: Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine, Journal of Cosmetic Dermatology, 2007 Mar, 6(1): 20-6; The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin, Journal of Cosmetic Science, 2009 Jul-Aug, 60(4): 423-8; Topical n-acetylglucosamine provides fast acne-reducing benefits and mildness demonstrating its potential utility in enhancing conventional Rx or OTC acne treatments, Journal of the American Academy of Dermatology, February 2007, Volume 56, Issue 2, Supplement 2, Page AB19; Oral N-acetylglucosamine supplementation improves skin conditions of female volunteers: Clinical evaluation by a microscopie three-dimensional skin surface analyzer, Journal of Applied Cosmetology 20, 143-152, April/June 2002; A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Décolletage, Joel Schlessinger, MD1 and Barbara Green, RPh, MS2 and Brenda L. Edison, BA2 and Lynn Murphy, MA2 and Yamini Sabherwal, PhD; Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes, Osteoarthritis and Cartilage, 2009 Aug, 17(8): 1022–1028; N-acetylglucosamine reduces inflammatory response during acute peritonitis in uremic rats, Blood Purification, 2006, 24(3): 274-81; Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitro, Journal of Cosmetic Dermatology, 2007 Dec, 6(4): 232-8; Cosmeceuticals for Hyperpigmentation: What is Available?, Journal of Cutaneous and Aesthetic Surgery, 2013 Jan-Mar, 6(1): 4–11.

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